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Related Concept Videos

Coagulation01:09

Coagulation

9.3K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Capillary Electrophoresis: Instrumentation01:20

Capillary Electrophoresis: Instrumentation

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Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
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Related Experiment Video

Updated: Dec 17, 2025

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Comprehensive Blood Coagulation Profiling in Patients Using iCoagLab: Comparison Against Thromboelastography.

Markandey M Tripathi1, Diane M Tshikudi1, Zeinab Hajjarian1

  • 1Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Thrombosis and Haemostasis
|June 24, 2020
PubMed
Summary
This summary is machine-generated.

A new optical device, iCoagLab, accurately profiles whole blood coagulation. It identifies patients at high bleeding risk with greater diagnostic accuracy and specificity than traditional methods, improving patient outcomes.

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Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Hematology

Background:

  • Delayed identification of coagulopathy increases organ failure and mortality risk in hospitalized patients.
  • Accurate point-of-care coagulation assessment is crucial for proactive bleeding risk identification and guiding resuscitation.

Purpose of the Study:

  • To evaluate the accuracy of a novel optical coagulation sensing approach, iCoagLab, for comprehensive whole blood profiling.
  • To investigate iCoagLab's diagnostic accuracy in identifying patients with elevated bleeding risk.

Main Methods:

  • Whole blood samples (N=270) were analyzed using iCoagLab and compared to mechanical thromboelastography (TEG).
  • iCoagLab measured time-varying laser speckle patterns to quantify clot viscoelastic modulus.
  • Coagulation parameters (R, K, α, MA) were derived and correlated between methods.

Main Results:

  • A strong correlation was found between iCoagLab and TEG parameters (p < 0.001).
  • iCoagLab demonstrated higher diagnostic accuracy (89%) and specificity (77%) for bleeding risk compared to TEG (87% and 69%).
  • iCoagLab achieved sensitivity (94%) identical to TEG.

Conclusions:

  • iCoagLab provides rapid and comprehensive blood coagulation profiling.
  • This novel optical sensing approach significantly advances the identification of patients at elevated bleeding risk.
  • Early identification of bleeding risk can prevent life-threatening hemorrhage and improve patient outcomes.