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[Functions of non-coding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells]
Jia-Hui Wen1, Yan-Min Wu1, Li-Li Chen1
1Dept. of Periodontology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
Abstract:
Human periodontal ligament-derived cells serve as an important source of seeding cells in periodontal regenerative medicine, and their osteogenic potential is closely related to alveolar bone repair and periodontal regeneration. Non-coding RNA (ncRNA), such as microRNA, long non-coding RNA, and circular RNA, play important roles in the regu-lation of osteogenic genes in human periodontal ligament-derived cells. In this review, we summarize the target genes, path-ways, and functions of the ncRNA network during osteogenic differentiation of periodontal ligament-derived cells.
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Master Transcription Regulators
lncRNA - Long Non-coding RNAs