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Updated: Dec 17, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
[Parenteral nutrition with preconceived bag in a preterm newborn ELBW.]
Susanna Bonafoni1, Caterina Alegiani1, Gianna Poloni1
1Neonatologia e Terapia Intensiva Neonatale, Ospedale S. Pietro Fatebenefratelli, Roma.
Insights
Parenteral nutrition (PN) is crucial for extremely low birth weight (ELBW) newborns. Standardized PN in pre-made bags offers a safe and balanced alternative when individualized preparations are not feasible.
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Intensive Care Medicine
Background:
- Adequate nutritional intake is vital for extremely low birth weight (ELBW) newborns.
- Parenteral nutrition (PN) supports early enteral feeding, aiming for intrauterine-like growth.
- PN ensures essential caloric, macro, and micronutrient delivery.
Observation:
- A case of an extremely preterm infant with multiple co-morbidities is presented.
- The infant experienced severe respiratory distress, cerebral hemorrhage, anemia, sepsis, and a patent ductus arteriosus.
- PN in a pre-established bag was utilized to support enteral feeding during clinical instability.
Findings:
- Standardized PN in pre-established bags provides balanced nutrition.
- This method reduces risks of microbiological contamination and preparation errors.
- PN is essential for ELBW preterms when enteral feeding is insufficient.
Implications:
- Pre-established PN bags are a viable alternative to individualized formulations.
- This approach supports growth in critically ill neonates.
- Ensuring adequate nutrition is key to managing ELBW infants.
Introduction:
The administration of adequate nutritional intake, from the first days of life, is of fundamental importance in the management of the newborn extremely low birth weight (ELBW): parenteral nutrition (PN), as a support for early enteral feeding, plays a central role in the attempt to guarantee a quantitative and qualitative growth similar to that of the fetus in utero, allowing an adequate caloric, macro and micronutrient intake. The standardized PN, carried out through pre-established bags, allows in the case in which is not possible a personalized preparation, balanced nutritional contributions, reducing the risk of microbiological contamination and errors in preparation.
Clinical Case:
We describe the case of an extremely preterm infant with various co-morbid conditions (severe respiratory syndrome, cerebral hemorrhage, anemia, sepsis and patency of the arterial duct) in which PN was used in a pre-established bag, as a support to enteral feeding in the first weeks of life, characterized by extreme clinical instability.
Conclusions:
PN is essential for some types of newborns and in particular for the ELBW preterms in which enteral feeding, although undertaken early, does not guarantee the necessary contributions to promote adequate growth. The use of NP in a pre-made bag can be a valid alternative to individualized formulations, where not available.
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