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Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease

Yu-Huang Liao1, Ming-Sheng Teng2, Jyh-Ming J Juang3,4

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei city, Taiwan.

Molecular Genetics & Genomic Medicine
|June 24, 2020
PubMed

Insights

Genetic variations in the LGALS3 gene significantly influence galectin-3 levels in coronary artery disease (CAD) patients. While galectin-3 levels correlate with inflammation markers, LGALS3 genotypes do not directly associate with these markers.

Area of Science:

  • Cardiovascular Genetics
  • Immunology
  • Molecular Biology

Background:

  • Galectin-3 is a key regulator of inflammation.
  • Coronary artery disease (CAD) involves complex inflammatory processes.
  • Understanding genetic influences on galectin-3 in CAD is crucial.

Purpose of the Study:

  • To investigate the association between LGALS3 gene polymorphisms, galectin-3 serum levels, and inflammatory markers in patients with CAD.
  • To determine the genetic contribution to galectin-3 levels in CAD.
  • To explore the relationship between galectin-3 levels and specific inflammatory markers.

Main Methods:

  • Genotyping of LGALS3 single nucleotide polymorphisms (SNPs) including rs2274273, rs4644, and rs4652.
  • Measurement of serum galectin-3 levels in 474 CAD patients.
  • Analysis of correlations between galectin-3 levels and various inflammatory markers (e.g., leukocyte count, C-reactive protein, ICAM-1, MMP-9).
  • Multivariate analysis to assess the impact of LGALS3 genotypes on galectin-3 level variation.

Main Results:

  • Significant correlations were observed between galectin-3 levels and leukocyte count, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 (p < .05).
  • LGALS3 genotypes (rs2274273, rs4644, rs4652) and haplotypes (CAC, CCC, ACT) were strongly associated with galectin-3 levels (p < 1.05 × 10⁻²⁵).
  • LGALS3 rs2274273 and rs4644 genotypes explained 20.8% of the variation in galectin-3 levels.
  • No association was found between LGALS3 genotypes and other measured inflammatory marker levels.

Conclusions:

  • Galectin-3 levels in CAD patients are strongly influenced by genetic factors related to the LGALS3 gene.
  • Elevated galectin-3 levels, but not specific LGALS3 genotypes, are associated with increased inflammatory markers in CAD.
  • Further research is warranted to clarify the role of galectin-3 in the pathogenesis of chronic inflammatory diseases.
Abstract

Keywords:
CADGalectin-3LGALS3 SNP

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