Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

351
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
351
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

325
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
325
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

362
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
362
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.6K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.6K
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

352
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
352
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

372
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
372

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of atopic dermatitis on education and career choices: the Scars of Life international study.

The Journal of investigative dermatology·2026
Same author

The Long-Term Impact of Childhood and Adolescent Atopic Dermatitis on Physical and Psychosocial Well-Being: Scars of Life project.

Clinical and experimental dermatology·2026
Same author

More than a symptom: itch as an independent clinical contributor in atopic dermatitis - a global-scale study on 15,223 patients.

The British journal of dermatology·2026
Same author

Retrospective Assessment of Social Rejection Related to Atopic Dermatitis During Childhood and Adolescence: The Scars of Life-Eczema Study.

International journal of dermatology·2026
Same author

Rapid, Strong, and Visible Efficacy of a Dermocosmetic in Acne Patients With Dark Skin Phototypes: Results of a Randomized Split-Face Study.

Journal of cosmetic dermatology·2026
Same author

Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study.

Journal of cosmetic dermatology·2026

Related Experiment Video

Updated: Dec 17, 2025

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

489

Treating Inflammation in Rosacea: Current Options and Unmet Needs.

Jerry Tan, J Mark Jackson

    Journal of Drugs in Dermatology : JDD
    |June 24, 2020
    PubMed
    Summary

    Rosacea involves immune system dysregulation, leading to inflammation and persistent symptoms. New treatments are needed to achieve complete clearance for rosacea patients by targeting a broader range of inflammatory pathways.

    Area of Science:

    • Dermatology
    • Immunology
    • Neurovascular Science

    Background:

    • Rosacea pathogenesis involves dysregulated innate, adaptive, and neurovascular immune systems.
    • Inflammatory pathways are key drivers of rosacea signs and symptoms, including erythema, papules, and pustules.
    • Current therapies partially manage inflammation but rarely achieve complete symptom resolution.

    Purpose of the Study:

    • To highlight the need for novel therapeutic strategies in rosacea management.
    • To emphasize the requirement for treatments addressing the full spectrum of rosacea-related inflammation.
    • To advocate for the development of more efficacious agents for complete rosacea clearance.

    Main Methods:

    • Review of current understanding of rosacea pathophysiology.

    More Related Videos

    Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
    04:12

    Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

    Published on: January 19, 2024

    1.4K
    Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
    04:50

    Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

    Published on: May 16, 2025

    686

    Related Experiment Videos

    Last Updated: Dec 17, 2025

    Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
    07:36

    Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

    Published on: July 3, 2025

    489
    Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
    04:12

    Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

    Published on: January 19, 2024

    1.4K
    Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
    04:50

    Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

    Published on: May 16, 2025

    686
  • Analysis of existing treatment modalities and their limitations.
  • Identification of gaps in rosacea therapeutic approaches.

    • Main Results:

    • Rosacea is characterized by complex immune dysregulation.
    • Existing treatments offer symptomatic relief but not complete disease eradication.
    • A significant unmet need exists for more effective rosacea therapies.

    Conclusions:

    • Comprehensive treatment strategies targeting diverse inflammatory pathways are essential for rosacea.
    • Further research and development of novel agents are crucial for achieving complete patient clearance.
    • Addressing the multifaceted nature of rosacea inflammation is key to improving patient outcomes.