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Rotavirus vaccination and intussusception: a paradigm shift?
Volker Vetter1, Priya Pereira1, Bernd Benninghoff1
1GSK Vaccines , Wavre, Belgium.
Human Vaccines & Immunotherapeutics
|June 24, 2020
Summary
Rotavirus vaccination may prevent intussusception (IS) cases. Natural rotavirus infection is a risk factor for IS, suggesting vaccines could improve the benefit-risk profile by reducing IS incidence in infants.
Area of Science:
- Pediatrics
- Vaccinology
- Gastroenterology
Background:
- Rotavirus (RV) is a primary cause of severe gastroenteritis in young children.
- Concerns about intussusception (IS) risk in infants following RV vaccination exist.
- RV infection itself may be an independent risk factor for IS in infants.
Purpose of the Study:
- To evaluate the potential benefit of rotavirus vaccination in preventing intussusception (IS).
- To explore the role of natural rotavirus infection as a risk factor for IS.
- To refine the understanding of the RV vaccine benefit-risk profile regarding IS.
Main Methods:
- Review of existing literature on rotavirus infection, RV vaccination, and intussusception.
- Analysis of epidemiological data on IS incidence and its association with RV disease.
- Assessment of the etiological link between RV infection and IS development.
Main Results:
- Rotavirus disease is suggested as an independent risk factor for intussusception in infants.
- RV vaccination may offer a protective effect against IS by preventing RV infection.
- The positive benefit-risk profile of RV vaccination could be enhanced by IS prevention.
Conclusions:
- Rotavirus vaccination holds potential for reducing intussusception cases in infants.
- Further research is needed to precisely quantify the risk of IS attributable to rotavirus disease.
- Optimizing RV vaccination strategies may improve infant health outcomes by mitigating IS risk.
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