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Concomitant medications and immune checkpoint inhibitor therapy for cancer: causation or association?
Nadiya Hussain1, Muntaha Naeem1, David J Pinato1
1Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital , London, UK.
Abstract:
The majority of cancer patients assume concomitant medications for the treatment of cancer-related symptoms or co-morbidities. As immune checkpoint inhibitors expand in the treatment of a widening range of malignancies, drug-drug interactions have become an area of increasing interest due to the potential for some concomitant medications to exert immune-modulatory effects and influence outcomes from immunotherapy. Here, we review the evidence supporting this association across selected drug classes including antibiotics, proton pump inhibitors, metformin, and opioids.
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