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Three Novel COVID-19 Pneumonia Cases Successfully Treated With Lopinavir/Ritonavir

Tatsuhiko Wada1, Kosuke Shimode1, Takayuki Hoshiyama1,2

  • 1Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan.

Frontiers in Medicine
|June 24, 2020
PubMed

Insights

Lopinavir/Ritonavir (LPV/r) effectively treated non-severe COVID-19 pneumonia in three elderly patients. This antiviral treatment offers a potential option for managing mild Coronavirus Disease 2019 cases.

Area of Science:

  • Infectious Diseases
  • Virology
  • Pulmonology

Background:

  • The global spread of Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), necessitates effective treatment strategies.
  • Early outbreaks included community transmission following a cruise ship incident in Japan.

Observation:

  • Three patients admitted to Kitasato University Hospital presented with pneumonia.
  • COVID-19 diagnosis was confirmed via real-time reverse transcriptase-polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 nucleic acid.
  • All patients were diagnosed with non-severe COVID-19 pneumonia.

Findings:

  • Successful treatment of non-severe COVID-19 pneumonia was achieved using Lopinavir/Ritonavir (LPV/r).
  • The treatment was effective even in elderly patients.

Implications:

  • Lopinavir/Ritonavir (LPV/r) presents a viable therapeutic option for non-severe COVID-19 pneumonia.
  • This finding is particularly relevant for managing mild cases in the elderly population.

Keywords:
COVID-19LopinavirRitonavircruise shipelderly patienthyponatremia

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