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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Molecular insights and novel approaches for targeting tumor metastasis
Sabya Sachi Das1, Saad Alkahtani2, Priyanshu Bharadwaj3
1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India.
Abstract:
In recent years, due to the effective drug delivery and preciseness of tumor sites or microenvironment, the targeted drug delivery approaches have gained ample attention for tumor metastasis therapy. The conventional treatment approaches for metastasis therapy have reported with immense adverse effects because they exhibited maximum probability of killing the carcinogenic cells along with healthy cells. The tumor vasculature, comprising of vasculogenic impressions and angiogenesis, greatly depends upon the growth and metastasis in the tumors. Therefore, various nanocarriers-based delivery approaches for targeting to tumor vasculature have been attempted as efficient and potential approaches for the treatment of tumor metastasis and the associated lesions. Furthermore, the targeted drug delivery approaches have found to be most apt way to overcome from all the limitations and adverse effects associated with the conventional therapies. In this review, various approaches for efficient targeting of pharmacologically active chemotherapeutics against tumor metastasis with the cohesive objectives of prognosis, tracking and therapy are summarized.
Insights
Targeted drug delivery offers precise tumor metastasis therapy, overcoming conventional treatment side effects. Nanocarrier approaches targeting tumor vasculature show promise for effective treatment and improved patient outcomes.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery
Background:
- Conventional metastasis therapies cause significant adverse effects by damaging healthy cells alongside cancerous ones.
- Tumor growth and metastasis are critically dependent on tumor vasculature, involving vasculogenesis and angiogenesis.
- Targeted drug delivery systems are gaining attention for their precision in reaching tumor sites or the tumor microenvironment.
Purpose of the Study:
- To review various nanocarrier-based drug delivery approaches for targeting tumor vasculature in metastasis therapy.
- To summarize strategies for effective targeting of chemotherapeutics against tumor metastasis.
- To highlight the potential of targeted delivery for prognosis, tracking, and therapy of metastatic tumors.
Main Methods:
- Review of literature on nanocarrier-based drug delivery systems.
- Analysis of targeting strategies for tumor vasculature.
- Summary of approaches for chemotherapy delivery in tumor metastasis.
Main Results:
- Nanocarrier-based targeted drug delivery demonstrates potential for precise treatment of tumor metastasis.
- Targeting tumor vasculature offers an effective strategy to combat metastasis and associated lesions.
- Targeted approaches can overcome limitations and adverse effects of conventional therapies.
Conclusions:
- Targeted drug delivery systems, particularly those utilizing nanocarriers, are highly promising for advanced tumor metastasis therapy.
- Focusing on tumor vasculature offers a strategic advantage in developing effective anti-metastasis treatments.
- These approaches hold potential for integrated therapeutic strategies including prognosis, tracking, and treatment.
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