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Insights into predicting diabetic nephropathy using urinary biomarkers
Naseer Ullah Khan1, Jing Lin1, Xukun Liu1
1College of Life Science and Oceanography, Shenzhen University, Shenzhen 518060, PR China.
Biochimica Et Biophysica Acta. Proteins and Proteomics
|June 24, 2020
Summary
Early detection of diabetic nephropathy (DN) is crucial. New urinary biomarkers, including proteins and exosomes, show promise for identifying kidney damage and guiding treatment for diabetes complications.
Area of Science:
- Nephrology
- Diabetology
- Biomarker Discovery
Background:
- Diabetic nephropathy (DN) is a severe kidney complication of diabetes.
- Early detection is vital to slow kidney function loss and prevent disease progression.
- Urine is an ideal non-invasive sample for discovering kidney disease biomarkers.
Purpose of the Study:
- To review novel urinary biomarkers for early diabetic nephropathy.
- To highlight markers associated with kidney damage, inflammation, and oxidative stress.
- To assess the qualification and validation of these biomarkers in recent publications.
Main Methods:
- Literature review of recent publications on urinary biomarkers for DN.
- Focus on studies involving larger cohorts for biomarker qualification and validation.
- Analysis of proteins, peptides, and exosomes in urine samples.
Main Results:
- Identified various urinary proteins, peptides, and exosomes as potential early DN biomarkers.
- Highlighted markers linked to tubular and glomerular damage.
- Noted markers associated with inflammation and oxidative stress in DN.
Conclusions:
- Novel urinary biomarkers offer significant potential for early DN detection and monitoring.
- These biomarkers aid in understanding DN pathophysiology and disease progression.
- Further validation in larger cohorts is essential for clinical application in diabetes management.
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