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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
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Related Experiment Video

Updated: Dec 17, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Injectable Lipid-Based Depot Formulations: Where Do We Stand?

Lisa Rahnfeld1, Paola Luciani1

  • 1Pharmaceutical Technology Research Group, Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.

Pharmaceutics
|June 25, 2020
PubMed
Summary
This summary is machine-generated.

Lipid-based injectable depot formulations offer tunable drug delivery for parenteral drugs, improving patient compliance. This review critically examines lipid platforms and discusses requirements for ideal formulations and in vitro assay limitations.

Keywords:
implantsin situ forming systemsinjectable lipid depotliposomeslong-acting drug delivery systemoil-based solutionssolid particles

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Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Parenteral drug approvals, including biologics and complex APIs, necessitate advanced drug delivery systems.
  • Injectable depot formulations enhance drug availability, reduce injection frequency, and improve patient compliance.
  • Lipids are favored excipients for depot systems due to their biocompatibility and safety.

Purpose of the Study:

  • To review recent advancements in lipid-based sustained-release injectable depot platforms.
  • To critically evaluate the requirements for an ideal depot formulation.
  • To discuss challenges in manufacturing and limitations of in vitro release assays.

Main Methods:

  • Review of lipid-based sustained release platforms (oil-based solutions, liposomes, in situ forming systems, solid particles, implants) developed in the last 5 years.
  • Critical discussion of excipient selection, biocompatibility, and manufacturing challenges.
  • Analysis of current in vitro release assays for assessing translational potential.

Main Results:

  • Lipid-based platforms show promise for sustained parenteral drug delivery.
  • Ideal depot formulations require careful consideration of excipients, biocompatibility, and manufacturing processes.
  • Existing in vitro release assays have limitations in predicting in vivo performance.

Conclusions:

  • Lipid-based depot formulations are advancing, but challenges remain in achieving ideal performance.
  • Further development is needed to optimize manufacturing and in vitro-in vivo correlation for depot injectables.
  • Biocompatible lipids offer a promising avenue for developing effective long-acting injectable drug delivery systems.