Application of Genetically Engineered Pigs in Biomedical Research

Area of Science:

• Biotechnology
• Genetics
• Animal Science

Background:

• Genetic engineering has enabled the creation of transgenic animals.
• Transgenesis offers applications in breeding, animal health, product quality, and biomedicine.
• Transgenic animals serve as models for gene function, human diseases, biopharmaceutical production, and xenotransplantation.

Purpose of the Study:

• To review the applications of genetically modified pigs in biomedical research.
• To discuss the use of transgenic pigs as models for human diseases.
• To explore the potential of transgenic pigs in biopharmaceutical production and xenotransplantation.

Main Methods:

• Review of existing literature on transgenic animal technology.
• Analysis of studies focusing on genetically modified pigs for research and clinical applications.
• Evaluation of the suitability of pigs for xenotransplantation and disease modeling.

Main Results:

• Pigs are identified as highly suitable models for human diseases due to biological similarities.
• Transgenic pigs are valuable for producing recombinant proteins and other biopharmaceuticals.
• Pigs are considered optimal donors for xenotransplantation due to physiological compatibility and reproductive traits.

Conclusions:

• Genetically modified pigs represent a significant advancement in biomedical research.
• Pigs offer a promising platform for developing disease models, producing biopharmaceuticals, and advancing xenotransplantation.
• Future research should address challenges and expand the use of swine models in medicine.