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Polymorphic Appetite Effects on Waist Circumference Depend on rs3749474 CLOCK Gene Variant.

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The CLOCK gene variant rs3749474 influences waist circumference based on appetite levels. Risk allele carriers experienced a significant increase in waist circumference related to appetite status.

Keywords:
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Area of Science:

  • Chronobiology
  • Genetics
  • Obesity Research

Background:

  • Chronobiological factors, particularly CLOCK genes, are linked to obesity.
  • Existing research shows CLOCK gene associations with energy intake and abdominal obesity.
  • The interplay between CLOCK gene variants, appetite, and chrononutrition requires further investigation.

Purpose of the Study:

  • To investigate interactions between CLOCK genetic variants and appetite status.
  • To identify how these interactions affect adiposity-related variables.

Main Methods:

  • Recruited 442 participants (329 women, 113 men) aged 18-65.
  • Collected anthropometric, dietary, and lifestyle data.
  • Utilized multiple linear regression and Bonferroni correction to analyze genotype x appetite status interactions on adiposity.

Main Results:

  • A significant interaction was found between appetite status and the rs3749474 CLOCK polymorphism on waist circumference (p < 0.001).
  • Carriers of the risk allele for rs3749474 showed an approximate 14 cm increase in waist circumference per appetite level increment.
  • Appetite's effect on waist circumference appears modulated by the rs3749474 CLOCK polymorphism.

Conclusions:

  • The rs3749474 CLOCK gene variant plays a role in modulating the relationship between appetite and waist circumference.
  • Chrononutrition research should consider genetic predispositions like CLOCK polymorphisms in relation to appetite and obesity.