Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Triple-negative breast cancer (TNBC) presents a significant global health challenge, characterized by high mortality rates.
• Chemoresistance and the absence of targeted therapies impede effective treatment, leading to poor prognosis and frequent recurrence in TNBC patients.
• Long non-coding RNAs (lncRNAs) are increasingly recognized for their critical roles in cellular functions and cancer progression, including TNBC.

Purpose of the Study:

• To review the involvement of lncRNAs in the mechanisms of chemoresistance in triple-negative breast cancer.
• To highlight the potential of lncRNAs as predictive biomarkers for chemoresistance in TNBC.
• To explore therapeutic strategies targeting lncRNAs for improved TNBC treatment.

Main Methods:

• Literature review focusing on the role of lncRNAs in TNBC chemoresistance.
• Analysis of studies investigating lncRNA expression and function in drug-resistant TNBC models.
• Synthesis of current research on lncRNA-targeted therapies for TNBC.

Main Results:

• lncRNAs are implicated in various drug-resistant mechanisms within TNBC.
• Aberrant lncRNA expression is associated with treatment failure and poor outcomes in TNBC.
• Targeting specific lncRNAs shows promise in overcoming chemoresistance in preclinical TNBC models.

Conclusions:

• lncRNAs represent a critical factor in TNBC chemoresistance.
• Targeting lncRNAs offers a promising avenue for novel therapeutic interventions in triple-negative breast cancer.
• Further research into lncRNA functions and therapeutic targeting is crucial for advancing TNBC treatment strategies.