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Cellular angiofibroma of the orbit
G J Hötte1, R M Verdijk1,2, M Gardeniers3
1Department of Oculoplastic, Orbital and Lacrimal Surgery, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
Orbit (Amsterdam, Netherlands)
|June 25, 2020
Summary
This study reports the first case of cellular angiofibroma, a benign mesenchymal tumor, found in the orbit. Histopathology confirmed the diagnosis in a 58-year-old male patient.
Area of Science:
- Ophthalmology
- Pathology
- Oncology
Background:
- Cellular angiofibroma is a rare benign mesenchymal tumor typically found in the genital tract.
- Extragenital occurrences are uncommon, making orbital involvement exceptionally rare.
Observation:
- A 58-year-old male presented with a two-year history of a superomedial orbital mass.
- MRI revealed a well-defined lesion with characteristic signal intensities and enhancement patterns.
- The mass was surgically excised via a medial upper eyelid crease incision.
Findings:
- Histopathological examination identified a vascular, CD34-positive, STAT6-negative spindle cell tumor.
- The tumor exhibited monoallelic loss of FOXO1, confirming the diagnosis of cellular angiofibroma.
- This represents the first documented instance of cellular angiofibroma originating in the orbit.
Implications:
- This case expands the known anatomical distribution of cellular angiofibroma.
- Highlights the importance of considering rare diagnoses in orbital masses.
- Contributes to the understanding of the histopathological spectrum of mesenchymal tumors.
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