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Updated: Dec 17, 2025
Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis
Sonia Aroui1, Hamadi Fetoui2, Abderraouf Kenani3
1Laboratory of Biochemistry, Research Unit: UR 12ES08 "Cell Signaling and Pathologies", Faculté de Médecine de Monastir, University of Monastir, 5019, Monastir, Tunisia. sonia_aroui2002@yahoo.fr.
Background:
Flavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plant-secondary metabolites with a polyphenolic structure and have properties with health-improving potential. Yet, not so many experimental focus on the benefits of flavonoid in vivo after external application. Here we assessed the impacts of naringin in vitro and in vivo in the human glioma U-87 cells implanted into athymic mice.
Methods:
Tumor size and animal survival time were followed in naringin-treated mice bearing subcutaneous gliomas. To define the effects of naringin on angiogenesis, in vitro, tube formation and migration were assayed using endothelial HUVEC cell line.
Results:
Low concentration of naringin remarkably inhibited tubulogenesis and reduced cell invasion. Moreover, naringin has been shown to have a toxicity effect on U-87 cells in a dose-dependent way. Furthermore, naringin administration (120 mg/kg/day) applies serious anti-cancer belongings on glioblastoma, as demonstrated by a slow cancer progression.
Conclusions:
Our study has provided the first evidence on the antitumor effect of naringin, which is somehow due to the inhibition of invasion and angiogenesis.
