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Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

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LAG3 (CD223) and autoimmunity: Emerging evidence.

Suiyuan Hu¹, Xu Liu¹, Tianding Li²

¹Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.

Journal of Autoimmunity

|June 25, 2020

Summary

Lymphocyte activation gene-3 (LAG3) is a novel immune checkpoint molecule. Targeting LAG3 offers new immunotherapy perspectives, especially in combination with anti-PD1 therapy, for various diseases.

Keywords:

Autoimmunity Immune checkpoint molecules Immunotherapy Inhibitory receptors LAG3

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Area of Science:

Immunology and Cancer Biology
Molecular and Cellular Biology

Background:

Immune checkpoints like CTLA4 and PD1 are crucial for immune homeostasis and cancer treatment.
Limited patient response to current therapies necessitates identifying novel immune checkpoints.
Lymphocyte activation gene-3 (LAG3) is an emerging inhibitory receptor expressed on multiple immune cells.

Purpose of the Study:

To review the current understanding of Lymphocyte Activation Gene-3 (LAG3).
To explore LAG3's structure, isoforms, ligands, signaling, and function.
To discuss LAG3's role in diseases and its potential as an immunotherapy target.

Main Methods:

Comprehensive literature review of studies on LAG3.
Analysis of LAG3's expression patterns and cellular functions.
Evaluation of LAG3's role in immune tolerance and disease pathogenesis.

Main Results:

LAG3 exhibits unique signaling properties and synergistic effects with anti-PD1 therapy.
LAG3 is implicated in maintaining immune tolerance and is a target in ongoing clinical trials.
Emerging evidence suggests LAG3's association with autoimmune diseases.

Conclusions:

LAG3 represents a promising target for novel immunotherapies, particularly in combination treatments.
Further research into LAG3's role in autoimmune diseases is warranted.
Targeting LAG3 holds significant potential for advancing cancer immunotherapy and managing immune-related disorders.