Areas of white matter hyperintensities and motor symptoms of Parkinson disease

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

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Yoonju Lee1, Jeongmin Ko1, Ye Eun Choi1

  • 1From the Department of Health Promotion (Y.L.), Severance Check-up, Yonsei University Health System, Seoul; Department of Neurology (Y.L.), Yonsei University College of Medicine, Seoul; Department of Neurology (J.K., J.Y.H.), Yonsei University Wonju College of Medicine, Wonju; Department of Nuclear Medicine (Y.E.C., J.S.O., J.S.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; INFINITT Healthcare (Y.E.C.), Seoul; Department of Neurology (M.K.S.), Bundang Jesaeng General Hospital, Seongnam; Department of Neurology (J.H.Y.), Ajou University School of Medicine, Suwon; and Department of Neurology (S.Y.K.), Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, South Korea.

Neurology
|June 25, 2020
PubMed
Abstract

Insights

Deep white matter hyperintensities impact bradykinesia in Parkinson disease (PD), while periventricular hyperintensities affect both bradykinesia and axial symptoms, independent of dopamine loss.

Area of Science:

  • Neurology
  • Neuroimaging
  • Neurodegeneration

Background:

  • White matter hyperintensities are common in Parkinson disease (PD).
  • Their differential impact on motor symptoms is not fully understood.

Purpose of the Study:

  • To investigate if deep white matter hyperintensities (DWMH) and periventricular hyperintensities (PVH) differentially affect motor symptoms in early Parkinson disease (PD).

Main Methods:

  • Analysis of MRI and dopamine transporter imaging in 93 de novo PD patients.
  • Visual rating scales for DWMH and PVH, Unified Parkinson's Disease Rating Scale (UPDRS) motor subscores.
  • Multivariable linear regression models adjusted for dopaminergic depletion.

Main Results:

  • Bradykinesia and axial symptoms correlated with both DWMH and PVH.
  • DWMH associated with bradykinesia; PVH associated with bradykinesia and axial symptoms.
  • Associations remained significant after adjusting for clinical factors and dopamine transporter availability.

Conclusions:

  • DWMH and PVH are independently associated with specific motor deficits in PD.
  • These white matter changes contribute to motor symptoms beyond dopaminergic neurodegeneration.

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