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The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects

Hannah M Stoveken1, Stefano Zucca1, Ikuo Masuho1

  • 1Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA.

The Journal of Biological Chemistry
|June 25, 2020
PubMed

Keywords:
G protein-coupled receptor (GPCR)G protein-coupled receptor 139 (GPR139)GIRK channelGPCR signalingadenylate cyclase (adenylyl cyclase)braincell signalingcellular regulationheterotrimeric G proteinmedial habenulaneuronopiate opioidopioidsorphan receptor

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