Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Dec 17, 2025

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Published on: July 25, 2025

Comparing Heterotopic Ossification in Two Cervical Disc Prostheses.

Xiaoyu Yang¹, Roland Donk², Ronald H M A Bartels³

¹Department of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands.

|June 25, 2020

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Equipoise in Neurosurgical Trials: Ethical Considerations and Challenges for Trial Conduct.

Neurosurgery·2026

Same author

Evaluation of bony fusion after posterior lumbar interbody fusion: a systematic review and meta-analysis.

Brain & spine·2026

Same author

Wrist Circumference-Dependent Thresholds for the Median Nerve in Carpal Tunnel Syndrome: A Cross-Cohort Comparison.

Journal of brachial plexus and peripheral nerve injury·2026

Same author

The management of severe isolated traumatic brain injury in pregnancy: A joint consensus statement from the European Association of Neurosurgical Societies (EANS) and the World Society of Emergency Surgery (WSES).

Brain & spine·2026

Same author

Enhanced MIF/CD74 axis activity shapes B cell functioning following traumatic spinal cord injury.

Journal of neuroinflammation·2026

Same author

Individualised stimlation parameters in deep brain stimulation for Parkinson's disease based on disease phenotype and brain connectivity: protocol for a randomised feasibility study in a tertiary care centre (iDBS trial).

BMJ open·2026

Heterotopic ossification (HO) occurred similarly in patients receiving activC or Bryan cervical disc prostheses. Clinical outcomes were comparable, though the Bryan prosthesis offered greater global range of motion (ROM).

Area of Science:

Spine surgery
Orthopedic biomechanics
Biomaterials in medicine

Background:

Cervical arthroplasty aims to preserve segmental range of motion (ROM).
Significant controversy exists regarding the incidence of heterotopic ossification (HO) with different cervical disc prostheses.
Understanding HO development is crucial for evaluating prosthesis efficacy and patient outcomes.

Purpose of the Study:

To compare the incidence of heterotopic ossification (HO) between the activC and Bryan cervical disc prostheses.
To evaluate clinical outcomes, including neck disability index (NDI), and range of motion (ROM) after implantation of these prostheses.
To investigate the relationship between prosthesis design and HO development.

Main Methods:

Retrospective analysis of data from two randomized clinical trials (NECK and PROCON).

More Related Videos

Anterior Cervical Discectomy and Fusion in the Ovine Model

Anterior Cervical Discectomy and Fusion in the Ovine Model

Published on: October 5, 2009

Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration

Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Dec 17, 2025

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Published on: July 25, 2025

Anterior Cervical Discectomy and Fusion in the Ovine Model

Anterior Cervical Discectomy and Fusion in the Ovine Model

Published on: October 5, 2009

Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration

Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration

Published on: January 26, 2024

Patients underwent anterior cervical discectomy with either the activC or Bryan prosthesis for cervical radiculopathy.

HO was assessed using the McAfee-Mehren classification at 12 and 24 months postoperatively. ROM and clinical outcomes (NDI, PCS, MCS) were also measured.

Main Results:

At 2-year follow-up, HO incidence was 68% for activC (55% severe) and 85% for Bryan (44% severe), with no significant difference (P=0.12).
HO progression was similar between the two groups.
While the Bryan group showed significantly greater global ROM (56.4° vs. 49.5°, P=0.044), clinical outcomes (NDI, PCS, MCS) were comparable between groups.

Conclusions:

Cervical disc prosthesis architecture does not influence the development of heterotopic ossification.
Although the Bryan prosthesis provided greater global ROM, this difference was not considered clinically significant.
Patient clinical condition was comparable regardless of HO severity, suggesting HO may not be a primary determinant of outcome.