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3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total

Yuji Sumii1,2, Naoyuki Kotoku1,3, Chisu Han1

  • 1Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.

Tetrahedron Letters
|June 25, 2020
PubMed

Keywords:
Aaptamine derivativeAntimicrobialDormantTuberculosis

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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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