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microRNAs targeting cellular cholesterol: implications for combating anticancer drug resistance

Bernice Monchusi1, Mandeep Kaur1

  • 1School of Molecular and Cell Biology, University of Witwatersrand, Wits, Johannesburg, South Africa.

Genes & Cancer
|June 25, 2020
PubMed

Insights

MicroRNAs (miRNAs) regulate genes involved in cholesterol metabolism. Targeting specific miRNAs like hsa-miR-128 and hsa-miR-223 may overcome drug resistance in breast cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Over 60% of mammalian protein-coding genes are regulated by microRNAs (miRNAs).
  • miRNA dysregulation is linked to cancer, influencing tumorigenesis and drug resistance.
  • Cholesterol accumulation fuels tumor growth and contributes to drug resistance in cancer cells.

Purpose of the Study:

  • To investigate the role of miRNAs in cholesterol-mediated drug resistance in breast cancer.
  • To consolidate evidence on miRNAs controlling cholesterol metabolism and their link to cancer drug resistance.
  • To explore potential therapeutic strategies targeting miRNAs for overcoming drug resistance.

Main Methods:

  • Literature review and collation of published evidence.
  • Computational tools analysis to explore miRNA roles.
  • Focus on breast cancer cells and cholesterol metabolism.

Main Results:

  • hsa-miR-128 and hsa-miR-223 were identified as key regulators.
  • These miRNAs target genes involved in lipid signaling, cholesterol metabolism, and breast cancer pathways.
  • Evidence supports their role in mediating cholesterol-driven drug resistance.

Conclusions:

  • miRNAs controlling cholesterol metabolism are implicated in cancer drug resistance.
  • Targeting hsa-miR-128 and hsa-miR-223 presents a potential strategy to combat drug resistance in breast cancer.
  • Further research into miRNA-based therapies could enhance cancer treatment outcomes.
Keywords:
cancer drug resistancecholesterolhsa-miR-128hsa-miR-223miRNAs

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