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Related Concept Videos

Spinal Nerves: Plexus I01:22

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Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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The subclavian artery transitions into the axillary artery as it exits the chest and enters the axillary region. This artery is critical for supplying blood to the shoulder area, including the head of the humerus, through the humeral circumflex arteries. As the vessel continues into the upper arm or brachium, it becomes the brachial artery. This artery plays a key role in vascularizing the brachial region and bifurcates at the elbow into several branches. These branches include the deep...
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Related Experiment Video

Updated: Dec 17, 2025

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
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Upper limb entrapment neuropathies in multiple sclerosis.

Han Yin1, Krishnan Ps Nair2, Dasappaiah G Rao2

  • 1Northern General Hospital, Sheffield Teaching Hospital NHS Foundation Trust, UK.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
|June 25, 2020
PubMed
Summary

Entrapment neuropathies like carpal tunnel syndrome are common in multiple sclerosis patients. Ulnar nerve entrapment risk is higher for those using powered wheelchairs, impacting hand function and independence.

Keywords:
Multiple sclerosiscarpal tunnel syndromecubital tunnel syndrome.entrapment neuropathiesrehabilitationupper limb

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Area of Science:

  • Neurology
  • Neurophysiology

Background:

  • Entrapment neuropathies (e.g., carpal tunnel syndrome) are prevalent.
  • Diagnosing upper limb entrapment neuropathies in multiple sclerosis (MS) patients is challenging due to overlapping symptoms.
  • Hand weakness in advanced MS can impair mobility and independence.

Purpose of the Study:

  • To investigate the prevalence and risk factors of upper limb entrapment neuropathies in multiple sclerosis patients.

Main Methods:

  • Retrospective review of 71 multiple sclerosis patients over 10 years.
  • Clinical neurophysiological studies were used to confirm entrapment neuropathies.
  • Demographic, clinical, and mobility aid data were collected.

Main Results:

  • 53.5% of MS patients had confirmed upper limb entrapment neuropathies.
  • Ulnar nerve entrapment was more common (53%) than median nerve entrapment (31%).
  • Powered wheelchair users had a significantly higher risk of ulnar nerve entrapment (OR 5.7).

Conclusions:

  • Consider entrapment neuropathies in multiple sclerosis patients with hand symptoms.
  • Early diagnosis and management are crucial for maintaining function in MS patients.