Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antibody-mediated diversification of primary and secondary humoral immune responses.

The Journal of experimental medicine·2026

Same author

B lymphocyte protein factories produced by hematopoietic stem cell gene editing.

Science (New York, N.Y.)·2026

Same author

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes.

Immunity·2026

Same author

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.

bioRxiv : the preprint server for biology·2026

Same author

Memory B cell development in response to mRNA SARS-CoV-2 and nanoparticle immunization in mice.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Antibody Mediated Diversification of Primary and Secondary Immune Responses.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Dec 17, 2025

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses.

Fabian Schmidt¹, Yiska Weisblum¹, Frauke Muecksch¹

¹Laboratory of Retrovirology, The Rockefeller University, 1230 York Avenue, New York NY 10028.

Biorxiv : the Preprint Server for Biology

|June 25, 2020

Summary

Developing rapid assays to measure SARS-CoV-2 antibody activity is crucial. These novel surrogate virus assays accurately assess neutralizing antibody potency from infection or vaccination.

More Related Videos

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

Related Experiment Videos

Last Updated: Dec 17, 2025

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

Area of Science:

Virology
Immunology
Infectious Diseases

Background:

The COVID-19 pandemic necessitates methods to quantify SARS-CoV-2 neutralizing antibodies.
Assessing antiviral activity is vital for understanding immunity from infection and vaccination.

Conclusions:

Developed surrogate virus assays provide reliable measurement of SARS-CoV-2 neutralizing antibody activity.
These assays are valuable tools for evaluating serologic immunity post-vaccination or infection.
Potency of convalescent plasma and monoclonal antibodies can be effectively assessed.