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IL-2-dependent proliferation of thymic accessory cells
B Rocha1, A Lehuen, M Papiernik
1Institut National de la Santé et de la Recherche Médicale U 25, Centre National de la Recherche Scientifique UA 122 Hôpital Necker, Paris, France.
Phagocytic cells of the thymic reticulum are Ia-positive accessory cells continuously produced in long term thymic stroma cultures. We show in the present paper that phagocytic cells of the thymic reticulum have R for IL-2. They share this property with splenic accessory cells produced in vitro by the same technique but have the unique property of proliferating in the presence of rIL-2. This proliferation is not enhanced by Con-A, is not linked to a lymphoid contaminant, and is specifically inhibited by an anti-IL-2R mAb.
Phagocytic cells of the thymic reticulum are Ia-positive accessory cells continuously produced in long term thymic stroma cultures. We show in the present paper that phagocytic cells of the thymic reticulum have R for IL-2. They share this property with splenic accessory cells produced in vitro by the same technique but have the unique property of proliferating in the presence of rIL-2. This proliferation is not enhanced by Con-A, is not linked to a lymphoid contaminant, and is specifically inhibited by an anti-IL-2R mAb.