Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

14.6K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
14.6K
Prochirality02:05

Prochirality

4.7K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clicking 1,4-Dithiin Conjugated Dimaleimides for Chiroptical Evolution and Nanofabrication.

Nano letters·2026
Same author

Chalcogen-bonding-mediated chiral recognition and enantioenrichment of organoselenocyanates.

Chemical science·2026
Same author

Coordinatively improving polymeric phosphorescence lifetime and quantum yield via triplet exciton modulation.

Nature communications·2026
Same author

Microporous Confinement of One-Dimensional Covalent Organic Frameworks for Surface-Regulated Photocatalytic Hydrogen Evolution.

Journal of the American Chemical Society·2026
Same author

Ï€-low transition temperature mixtures with widely-tunable polarity and ultralow viscosity for synthesizing chiral nanomaterials.

Nature communications·2026
Same author

Solvent-Gated Multimodal Charge Transfer Interactions for Precise Supramolecular Chirality Control.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Dec 17, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.1K

Modular Molecular Self-Assembly for Diversified Chiroptical Systems.

Zhuoer Wang1, Heng Zhang1, Aiyou Hao1

  • 1School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|June 25, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a modular, ternary molecular self-assembly strategy for creating chiral nanostructures. This approach overcomes challenges in multicomponent systems, yielding advanced materials with tunable chiroptical properties and high fidelity.

Keywords:
Cotton effectsaromatic amino acidschiroptical systemscircular polarized luminescenceself-assemblyternary coassembly

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.8K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.3K

Related Experiment Videos

Last Updated: Dec 17, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.1K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.8K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.3K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Bottom-up molecular self-assembly is key for fabricating chiral nanostructures with specific chiroptical activities like circular polarized luminescence (CPL).
  • Existing multicomponent coassembly methods often face complexity, leading to low yields and poor fidelity, hindering the rational design of sophisticated chiral systems.

Purpose of the Study:

  • To develop a modular, ternary molecular self-assembly strategy for creating complex, chiroptically active materials.
  • To overcome the inherent challenges associated with multicomponent coassembly, improving yield and fidelity.
  • To explore the generation of supramolecular chirality and tunable CPL emission in hierarchical nanostructures.

Main Methods:

  • Utilized N-terminated aromatic amino acids functionalized with binding sites for charge transfer and hydrogen bonding.
  • Implemented a modular, ternary coassembly approach to control supramolecular chirality and luminescent properties.
  • Investigated the formation of hydrogels and topological transitions in self-assembled nanostructures.

Main Results:

  • Achieved precise control over supramolecular chirality, including handedness and luminescent color.
  • Generated abundant CPL emission with high luminescence dissymmetry factor values.
  • Facilitated the formation of high-water-content hydrogels composed of super-helical nanostructures.
  • Observed a helix-to-toroid topological transition in the self-assembled structures.

Conclusions:

  • The modular ternary self-assembly strategy offers a robust method for fabricating complex chiral nanostructures with tunable chiroptical properties.
  • This approach provides a high-yield, high-fidelity pathway for designing multicomponent self-assembled systems.
  • The findings offer insights into mimicking biological coassembly processes and developing advanced functional materials.