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Related Experiment Videos

Complement kinetics during continuous arteriovenous hemofiltration: studies with a new polysulfone hemofilter.

A A Kaplan1, S Toueg, T L Kennedy

  • 1Department of Pediatrics, University of Connecticut Health Center, Farmington.

Blood Purification
|January 1, 1988
PubMed
Summary

The Renaflo polysulfone hemofilter is safe for continuous arteriovenous hemofiltration. While polysulfone membranes cause a minor, clinically insignificant increase in complement component C3a (complement component 3a), no adverse effects were observed.

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Area of Science:

  • Biomedical Engineering
  • Nephrology
  • Immunology

Background:

  • Continuous arteriovenous hemofiltration (CAVH) is a renal replacement therapy.
  • Polysulfone hemofilters are commonly used in CAVH.
  • Assessing the biocompatibility of hemofilters is crucial for patient safety.

Purpose of the Study:

  • To evaluate the biocompatibility of the Renaflo polysulfone hemofilter during CAVH treatments.
  • To investigate potential complement activation by the Renaflo filter.

Main Methods:

  • Biocompatibility was assessed by measuring pre- and postfilter levels of complement components (C3a, C4a, C5a) and leukocyte counts.
  • Measurements were taken at baseline and at 15, 60, and 90 minutes after filter placement.
  • The study included 15 patients undergoing CAVH.

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Main Results:

  • A statistically significant, though small, increase in postfilter C3a levels was observed (1,224 +/- 56 vs. 1,535 +/- 150 ng/ml, p < 0.01).
  • A similar increase in C3a was noted with an Amicon polysulfone filter.
  • No other significant changes in measured parameters or clinical symptoms of complement activation were detected.

Conclusions:

  • The Renaflo polysulfone hemofilter demonstrates acceptable biocompatibility for use in CAVH.
  • Polysulfone membranes induce a detectable, yet clinically insignificant, activation of C3.
  • The Renaflo filter is considered safe for clinical application in CAVH.