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Updated: Dec 17, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

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Self-Immolative Polyurethane-Based Nanoassemblies: Surface Charge Modulation at Tumor-Relevant pH and

Subrata Santra¹, Mursed A Sk¹, Arun Mondal¹

¹Department of Chemistry, University of Calcutta, 92 A.P.C. Road, Calcutta 700009, India.

Langmuir : the ACS Journal of Surfaces and Colloids

|June 25, 2020

Summary

Researchers developed a new amphiphilic polymer that self-assembles into micelles for drug delivery. This stimuli-responsive polymer degrades in response to reducing agents, releasing its payload.

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

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Published on: December 23, 2016

Area of Science:

Polymer Chemistry
Materials Science
Biomedical Engineering

Background:

Stimuli-responsive polymers are crucial for targeted drug delivery.
Amphiphilic polymers self-assemble into nanostructures for encapsulating therapeutic agents.
Developing biodegradable polymers with controlled release mechanisms is a key challenge.

Purpose of the Study:

To design and synthesize a novel amphiphilic polyurethane with redox-responsive and pH-responsive properties.
To investigate the self-assembly behavior and guest encapsulation of the synthesized polymer.
To evaluate the triggered degradation and drug release capabilities of the polymer.

Main Methods:

Synthesis of amphiphilic polyurethane with a redox-responsive self-immolative unit and hydrophilic pendant triethylene glycol.
Dynamic light scattering and transmission electron microscopy for micellar nanostructure investigation.
Zeta potential measurements for pH-responsive charge analysis.
UV-vis spectroscopy to probe guest release upon triggered degradation by glutathione.

Main Results:

The synthesized amphiphilic polymer self-assembles into micellar nanostructures in aqueous media.
The polymer exhibits pH-responsive behavior, forming positively charged nanoassemblies at tumor-relevant pH.
Redox-responsive degradation was observed in the presence of glutathione, leading to disassembly and guest release.

Conclusions:

The designed amphiphilic polymer demonstrates stimuli-responsive self-assembly, pH-specific charge generation, and triggered degradation.
These properties suggest potential applications in developing biodegradable supramolecular scaffolds for targeted drug delivery.
The triggered degradation and controlled release mechanism offer a promising strategy for advanced biomedical applications.