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Related Experiment Video

Updated: Dec 17, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Longitudinal Structural and Microvascular Observation in RCS Rat Eyes Using Optical Coherence Tomography Angiography.

Bingyao Tan1,1, Veluchamy A Barathi1,1, Emily Lin1

  • 1.

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|June 25, 2020
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Summary
This summary is machine-generated.

This study shows that swept source optical coherence tomography angiography (SS-OCTA) can detect retinal thinning and capillary loss in the deep capillary plexiform (DCP) layer of rats with retinitis pigmentosa.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Imaging

Background:

  • Retinitis pigmentosa (RP) is a group of inherited disorders that cause progressive vision loss.
  • Rodent models are crucial for understanding RP pathogenesis and testing therapies.
  • Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that visualizes retinal vasculature.

Purpose of the Study:

  • To evaluate changes in retinal thickness and ocular microvasculature in a rat model of retinitis pigmentosa (RP) using swept source optical coherence tomography angiography (SS-OCTA).

Main Methods:

  • Utilized a prototype SS-OCTA system to image Royal College of Surgeons (RCS) rats and age-matched controls.
  • Measured retinal layer thicknesses and analyzed enface angiograms of superficial (SVP) and deep capillary plexiform (DCP) layers.
  • Performed immunohistochemical analysis to confirm OCTA findings.

Main Results:

  • RCS rats exhibited progressive thinning of retinal layers and significant capillary loss in the DCP, but not the SVP.
  • SS-OCTA visualized RPE degeneration and choriocapillaris loss over time.
  • Control rats showed minimal age-related retinal thinning without vascular changes.

Conclusions:

  • Photoreceptor degeneration in RP is linked to DCP capillary loss, not SVP changes.
  • SS-OCTA is effective for characterizing structural and angiographic changes in rodent models of retinal disease.