Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.8K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines Update for the Role of Emerging Therapies in the Management of Patients With Metastatic Brain Tumors.

Neurosurgery·2025
Same author

Telehealth in Neurosurgery: 2021 Council of State Neurosurgical Societies National Survey Results.

World neurosurgery·2022
Same author

Mixed gangliocytoma-pituitary adenoma in MEN1 syndrome: A case report and literature review.

Neuropathology : official journal of the Japanese Society of Neuropathology·2022
Same author

Socioeconomic Implications of Professional Relationships within Modern Care Delivery Systems.

World neurosurgery·2021
Same author

Dual antivascular function of human fibulin-3 variant, a potential new drug discovery strategy for glioblastoma.

Cancer science·2020
Same author

Melanotic Neuroectodermal Tumor Presenting as Endolymphatic Sac Tumor.

Ear, nose, & throat journal·2019

Related Experiment Video

Updated: Dec 17, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.0K

Exploiting Cancer's Tactics to Make Cancer a Manageable Chronic Disease.

Kambiz Afrasiabi1, Mark E Linskey1, Yi-Hong Zhou1

  • 1Brain Tumor Research Laboratory, Department of Neurological Surgery, University of California, Irvine, CA 92617, USA.

Cancers
|June 26, 2020
PubMed
Summary

Cancer treatments have evolved significantly, but recurrence remains a challenge. Targeting cancer

Keywords:
cancer metabolismcancer stem cellchromosomal instabilitydominant cancer evolution strategiesevolution of cancer therapyfuture cancer therapeuticsintra-tumoral heterogeneitysurgical advances in gliomas

More Related Videos

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

9.3K
Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

1.8K

Related Experiment Videos

Last Updated: Dec 17, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.0K
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

9.3K
Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

1.8K

Area of Science:

  • Oncology and Cancer Biology
  • Cancer Therapeutics and Evolution

Background:

  • Modern oncology emerged ~80 years ago with cytotoxic agents and radiation therapy.
  • Advances include targeted therapies, anti-angiogenic agents, immunotherapy, and stem cell-targeting drugs.
  • Despite progress in cell killing and tumor removal, cancer recurrence persists.

Purpose of the Study:

  • To analyze the evolutionary tactics driving cancer recurrence and therapeutic resistance.
  • To propose a shift in therapeutic strategy towards delaying recurrence by targeting cancer evolution.

Main Methods:

  • Analysis of cancer evolutionary tactics: chromosomal instability (CIN), intra-tumoral heterogeneity (ITH), and cancer-specific metabolism.
  • Review of current therapeutic limitations in overcoming resistance driven by these tactics.

Main Results:

  • CIN, ITH, and altered metabolism are key evolutionary tactics enabling cancer resistance.
  • Current therapies, while effective at killing cells, fail to address these fundamental evolutionary mechanisms.

Conclusions:

  • Focusing on delaying cancer recurrence by targeting evolutionary tactics like CIN and ITH is crucial.
  • Understanding and controlling CIN and ITH can lead to improved therapeutic strategies.
  • Transforming cancer into a manageable chronic disease requires targeting its evolutionary underpinnings.