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T cell receptor alpha mRNA transcription in T-lymphoblastic transformation of chronic myelocytic leukemia
P Valent1, C R Bartram, T Radaszkiewicz
1Department of Medicine, University of Vienna, Austria.
Leukemia
|March 1, 1988
Abstract:
Analysis at the DNA and RNA level revealed a mature genetic marker profile in a case of T type blast crisis of chronic myelocytic leukemia. T cell receptor beta chain gene rearrangement as well as T cell receptor alpha mRNA transcription was demonstrated in blasts of the malignant clone. Corresponding findings were obtained from immunological phenotyping. Blasts were found to be CD7+, CD1+, CD3+, CD4+, CD8+, and TdT- and classified as common/mature thymocytes. The presence of the breakpoint cluster region gene on chromosome 22 excluded the possibility of a second neoplastic process.