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Related Experiment Videos

Cerebral blood flow changes during sodium-lactate-induced panic attacks.

R S Stewart1, M D Devous, A J Rush

  • 1Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.

The American Journal of Psychiatry
|April 1, 1988
PubMed
Summary

Patients with panic disorder show altered brain blood flow during panic attacks induced by lactate infusion. Unlike controls, those experiencing panic had reduced or unchanged cerebral blood flow.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Psychiatry

Background:

  • Panic disorder is a debilitating psychiatric condition.
  • Cerebral blood flow (CBF) alterations may underlie panic attacks.
  • Xenon-133 inhalation SPECT is a method to assess regional CBF.

Purpose of the Study:

  • To investigate regional cerebral blood flow (rCBF) in patients with panic disorder.
  • To compare rCBF during rest, saline infusion, and lactate infusion.
  • To determine if lactate-induced panic attacks correlate with specific CBF changes.

Main Methods:

  • Dynamic single-photon emission computed axial tomography (SPECT) using inhaled xenon-133.
  • Measurement of rCBF in 10 drug-free patients with panic disorder and 5 healthy controls.

Related Experiment Videos

  • Comparison of rCBF during rest and sodium lactate infusion.

    • Main Results:

    • Lactate infusion increased hemispheric blood flow in controls and non-panicked patients.
    • Patients experiencing lactate-induced panic attacks showed minimal increase or decrease in hemispheric blood flow.
    • This suggests a distinct hemodynamic response during panic attacks.

    Conclusions:

    • Panic attacks in panic disorder may be associated with altered cerebral hemodynamics.
    • Lactate challenge can unmask abnormal CBF responses in susceptible individuals.
    • Further research is warranted to explore the neurobiological mechanisms of panic disorder.