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Related Experiment Videos

Ranitidine in the newborn.

M Rosenthal1, P W Miller

  • 1North West Regional Perinatal Centre, St. Mary's Hospital, Manchester.

Archives of Disease in Childhood
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Ranitidine infusion effectively stopped severe gastrointestinal bleeding in a premature infant. This treatment offers a potential solution for critical bleeding in neonates.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Life-threatening gastrointestinal (GI) hemorrhage is a serious complication in premature infants.
  • Anuria, the absence of urine production, presents unique challenges in managing fluid and medication in neonates.

Purpose of the Study:

  • To evaluate the efficacy of ranitidine infusion in managing acute, severe GI bleeding in a preterm, anuric infant.

Main Methods:

  • A neonate of 30 weeks' gestation experiencing a critical GI bleed was treated with a continuous infusion of ranitidine.
  • The dosage administered was 0.2 mg/kg/hour.

Main Results:

  • The ranitidine infusion resulted in the abrupt cessation of the life-threatening gastrointestinal hemorrhage.

Related Experiment Videos

  • Hemostasis was achieved rapidly following the initiation of the ranitidine treatment.

    • Conclusions:

    • Continuous infusion ranitidine can be an effective therapeutic option for controlling severe GI bleeding in high-risk neonatal populations.
    • This case highlights the potential utility of ranitidine in managing emergent GI hemorrhage in anuric preterm infants.