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Related Concept Videos

Autism Spectrum Disorder01:19

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Can Maternal Autoantibodies Play an Etiological Role in ASD Development?

Iva Dudova1, Klara Horackova2, Michal Hrdlicka1

  • 1Department of Child Psychiatry, Charles University Second Faculty of Medicine, Prague, Czech Republic.

Neuropsychiatric Disease and Treatment
|June 26, 2020
PubMed
Summary

Maternal autoantibodies targeting fetal brain proteins, specifically collapsin response mediator proteins (CRMPs), may contribute to autism spectrum disorder (ASD) development by disrupting neurodevelopment. Further research into maternal antibodies related to ASD (MAR ASD) could reveal new treatment strategies.

Keywords:
CRMP2animal modelsautism spectrum disordermaternal autoantibodiestherapy

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Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with diverse genetic and environmental factors.
  • The maternal immune system and prenatal brain development are increasingly recognized as critical in ASD etiology.
  • Maternal autoantibodies targeting fetal brain proteins are a potential contributing factor to ASD, termed maternal antibodies related to ASD (MAR ASD).

Purpose of the Study:

  • To explore the role of collapsin response mediator proteins (CRMPs) in neurodevelopment and their potential involvement in ASD pathogenesis.
  • To discuss the implications of maternal autoantibodies targeting CRMPs in the context of MAR ASD.
  • To review potential future therapeutic avenues for MAR ASD.

Main Methods:

  • Review of existing clinical studies and animal models investigating maternal autoantibodies and ASD.
  • Discussion of the known functions of CRMP family proteins in neuronal development.
  • Analysis of how maternal autoantibody targeting of CRMPs could impact neurodevelopmental processes.

Main Results:

  • Maternal autoantibodies targeting fetal brain proteins, including CRMPs, are linked to ASD.
  • CRMPs play a crucial role in regulating neuron growth, guidance, and migration.
  • Antibody-mediated disruption of CRMP function may lead to neurodevelopmental defects implicated in ASD.

Conclusions:

  • Targeting of CRMPs by maternal autoantibodies presents a plausible mechanism in the etiology of certain ASD cases.
  • Understanding the role of CRMPs in MAR ASD opens possibilities for targeted diagnostic and therapeutic interventions.
  • Further elucidation of the precise mechanisms is needed to fully understand the contribution of MAR ASD to neurodevelopmental disorders.