Curcumin Supplementation Alleviates Polymyxin E-Induced Nephrotoxicity.

Area of Science:

• Pharmacology
• Nephrology
• Oxidative Stress Research

Background:

• Polymyxin E (PolyE) is a last-line antibiotic for multidrug-resistant gram-negative bacteria.
• PolyE use is limited by nephrotoxicity, potentially linked to oxidative stress.
• Curcumin (CUR) is a known potent antioxidant with potential therapeutic applications.

Purpose of the Study:

• To investigate the potential nephroprotective effects of Curcumin (CUR) against Polymyxin E (PolyE)-induced kidney injury in a mouse model.
• To evaluate CUR's ability to counteract PolyE-associated oxidative stress and histopathological damage.

Main Methods:

• Mice were administered PolyE (15 mg/kg/day) intravenously for 7 days.
• Groups received varying doses of Curcumin (CUR) (10, 100, 200 mg/kg) intraperitoneally concurrently with PolyE.
• Evaluated plasma creatinine, blood urea nitrogen, oxidative stress markers (ROS, LPO, GSH), and kidney histopathology.

Main Results:

• PolyE administration significantly increased plasma creatinine and blood urea nitrogen levels.
• PolyE induced significant oxidative stress, marked by increased ROS and LPO, and decreased GSH and antioxidant capacity.
• Histopathological examination revealed interstitial nephritis, tissue necrosis, and glomerular atrophy in PolyE-treated mice.
• CUR treatment dose-dependently alleviated PolyE-induced increases in oxidative stress markers and reversed kidney damage.

Conclusions:

• Curcumin (CUR) demonstrates significant nephroprotective properties against Polymyxin E (PolyE)-induced renal toxicity in mice.
• CUR effectively mitigates PolyE-induced oxidative stress and associated kidney damage.
• Further research is warranted to explore the clinical applicability of CUR for managing PolyE-induced nephrotoxicity.