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Curcumin Supplementation Alleviates Polymyxin E-Induced Nephrotoxicity

Afsaneh Vazin1, Reza Heidari2, Zahra Khodami1

  • 1Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Journal of Experimental Pharmacology
|June 26, 2020
PubMed
Abstract

Insights

Curcumin (CUR) shows protective effects against polymyxin E (PolyE)-induced kidney damage in mice. This antioxidant may help mitigate PolyE nephrotoxicity, warranting further clinical investigation.

Area of Science:

  • Pharmacology
  • Nephrology
  • Oxidative Stress Research

Background:

  • Polymyxin E (PolyE) is a last-line antibiotic for multidrug-resistant gram-negative bacteria.
  • PolyE use is limited by nephrotoxicity, potentially linked to oxidative stress.
  • Curcumin (CUR) is a known potent antioxidant with potential therapeutic applications.

Purpose of the Study:

  • To investigate the potential nephroprotective effects of Curcumin (CUR) against Polymyxin E (PolyE)-induced kidney injury in a mouse model.
  • To evaluate CUR's ability to counteract PolyE-associated oxidative stress and histopathological damage.

Main Methods:

  • Mice were administered PolyE (15 mg/kg/day) intravenously for 7 days.
  • Groups received varying doses of Curcumin (CUR) (10, 100, 200 mg/kg) intraperitoneally concurrently with PolyE.
  • Evaluated plasma creatinine, blood urea nitrogen, oxidative stress markers (ROS, LPO, GSH), and kidney histopathology.

Main Results:

  • PolyE administration significantly increased plasma creatinine and blood urea nitrogen levels.
  • PolyE induced significant oxidative stress, marked by increased ROS and LPO, and decreased GSH and antioxidant capacity.
  • Histopathological examination revealed interstitial nephritis, tissue necrosis, and glomerular atrophy in PolyE-treated mice.
  • CUR treatment dose-dependently alleviated PolyE-induced increases in oxidative stress markers and reversed kidney damage.

Conclusions:

  • Curcumin (CUR) demonstrates significant nephroprotective properties against Polymyxin E (PolyE)-induced renal toxicity in mice.
  • CUR effectively mitigates PolyE-induced oxidative stress and associated kidney damage.
  • Further research is warranted to explore the clinical applicability of CUR for managing PolyE-induced nephrotoxicity.
Keywords:
antibioticsmitochondrial impairmentnephrotoxicityoxidative stress

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