Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tuning in the bullfrog ear.

E R Lewis1

  • 1Electronics Research Laboratory, University of California, Berkeley 94720.

Biophysical Journal
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Electrical resonances in frog hair cells do not explain ear tuning. The complex interactions within the intact ear obscure these individual cell properties, challenging reductionist approaches in biology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic oscillations of coupled domain walls.

Physical review letters·2012
Same author

Tunable remote pinning of domain walls in magnetic nanowires.

Physical review letters·2011
Same author

Fast domain wall motion in magnetic comb structures.

Nature materials·2010
Same author

The Spread of Bacterial Infection: Further Studies on an Experimental Epidemic of Mouse-Typhoid.

The Journal of hygiene·2010
Same author

Immunisation and Selection as Factors in Herd-Resistance.

The Journal of hygiene·2010
Same author

The Rôle of the Twort-d'Herelle Phenomenon in Epidemics of Mouse-Typhoid.

The Journal of hygiene·2010
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026
Same journal

Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

Biophysical journal·2026
Same journal

Dynamic conformations of fluorophores on self-labeling protein tags.

Biophysical journal·2026
Same journal

Different actions of RyR2 open and closed channel block explained by a multiscale Ca<sup>2+</sup> release model.

Biophysical journal·2026
Same journal

Membrane Environment Sets the Functional pK<sub>a</sub> of Ionizable Lipids.

Biophysical journal·2026
See all related articles

Area of Science:

  • Auditory neuroscience
  • Bioacoustics
  • Cellular physiology

Background:

  • Electrical resonances in hair cells of lower vertebrates suggested a direct mechanism for auditory tuning.
  • Previous research focused on isolated cells, hinting at molecular explanations for hearing.
  • The frog sacculus is a key auditory organ in lower vertebrates.

Purpose of the Study:

  • To investigate whether observed electrical resonances in isolated frog hair cells contribute to the tuning properties of the intact frog sacculus.
  • To evaluate the validity of reductionist explanations for auditory function based on isolated cellular properties.

Main Methods:

  • Electrophysiological recordings from isolated frog sacculus hair cells.
  • Auditory tuning measurements of the intact frog sacculus.

Related Experiment Videos

  • Comparative analysis of data from isolated cells and the intact organ.

    • Main Results:

    • Electrical resonances observed in isolated frog hair cells were found to be completely obscured in the tuning properties of the intact frog sacculus.
    • The dynamic properties of the whole auditory system masked the contributions of individual cellular resonances.
    • This indicates that system-level interactions significantly influence auditory perception.

    Conclusions:

    • The tuning of the frog sacculus cannot be explained solely by the electrical resonances of its individual hair cells.
    • Reductionist approaches may fail to capture the full functional properties of complex biological systems.
    • Understanding auditory mechanisms requires considering the integrated behavior of the entire auditory system.