[Effect of interleukin-1 on adrenal function in mice]

The influence of macrophage secretion product on the functional activity of the adrenal glands has been studied in mice. It has been shown that intravenously injected interleukin-1 caused dose-dependent increase in corticosterone content in the blood plasma. The hormonal response of the adrenal glands to interleukin-1 injection was abolished by the inhibition of prostaglandin synthesis. The results obtained indicate that interleukin-1 stimulates the functional activity of the adrenal glands, with the effect mediated by prostaglandins.