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A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-l2)
Y S Fan1, J M Rowe, P D Dal Cin
1Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, New York.
Cancer Genetics and Cytogenetics
|April 1, 1988
Abstract:
We here report a t(9;11)(p11;q23) as the only abnormality in the affected cells of a 20-year-old male with acute lymphoblastic leukemia (L2) of T-cell origin. One hundred six patients with acute leukemia and involvement of band 11q23 were reviewed. Young age, hyperleukocytosis, and poor prognosis characterized almost all the cases in the acute leukemias with the 11q23 translocation, despite involvement of different recipient chromosomes and different morphologic and immunologic phenotypes.