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The Natural Polypeptides as Significant Elastase Inhibitors.

Shabir Ahmad1,2, Muhammad Saleem1, Naheed Riaz1

  • 1Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

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|June 26, 2020
PubMed
Summary

Human neutrophil elastase (HNE) causes tissue damage in inflammatory diseases. This review explores natural polypeptides as potential HNE inhibitors, addressing challenges in targeting elastase activity.

Keywords:
anti-inflammatoryelastasesmarine natural productsnatural productspolypeptides

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Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Human neutrophil elastase (HNE) is implicated in tissue destruction across numerous chronic inflammatory diseases.
  • Overexpression of HNE contributes to the pathogenesis of conditions like COPD, rheumatoid arthritis, and atherosclerosis.
  • Targeting HNE over-activation is a therapeutic strategy for inflammatory diseases, but specificity is challenging due to shared functions with other proteases.

Purpose of the Study:

  • To review natural polypeptides identified as potential inhibitors of human neutrophil elastase (HNE).
  • To correlate the mechanism of action, structural features, and activity of these polypeptide inhibitors.
  • To highlight the potential of natural compounds in developing novel therapeutic strategies for HNE-mediated inflammatory conditions.

Main Methods:

  • Literature review of scientific articles reporting natural polypeptides with elastase inhibitory activity.
  • Analysis of studies detailing the mechanism of action and structural characteristics of identified inhibitors.
  • Correlation of reported activities and structural features of natural elastase inhibitors.

Main Results:

  • Several natural polypeptides have been identified as potential inhibitors of human neutrophil elastase.
  • The review correlates available data on the mechanism of action, structural features, and inhibitory activity of these polypeptides.
  • Challenges in achieving specific elastase inhibition due to functional overlap with other serine proteases are discussed.

Conclusions:

  • Natural polypeptides represent a promising source for developing specific inhibitors of human neutrophil elastase.
  • Understanding their structure-activity relationships is crucial for designing effective therapeutics.
  • Further research into these natural compounds could lead to novel treatments for inflammatory diseases mediated by HNE.