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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression

Yinshan Jin1, Jiannan Liu1, Yadong Liu1

  • 1Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Frontiers in Pharmacology
|June 26, 2020
PubMed
Abstract

Insights

Oxymatrine effectively inhibits renal cell carcinoma progression by suppressing beta-catenin. This natural compound shows promise as an antitumor agent for treating kidney cancer.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Oxymatrine (OMT) exhibits known immunomodulatory, anti-inflammatory, and anticancer properties.
  • Renal cell carcinoma (RCC) is a significant health concern requiring novel therapeutic strategies.

Purpose of the Study:

  • To investigate the precise function of oxymatrine in renal cell carcinoma progression.
  • To elucidate the underlying molecular mechanisms of oxymatrine's action in RCC.

Main Methods:

  • In vitro studies utilized CCK-8 assays, cell cycle analysis, apoptosis assays, wound healing, and transwell assays to assess oxymatrine's antineoplastic effects.
  • Western blot and immunofluorescence assays were employed to analyze beta-catenin modulation by oxymatrine.
  • In vivo studies involved an animal model to evaluate oxymatrine's effect on tumor growth.

Main Results:

  • Oxymatrine demonstrated significant inhibition of RCC progression in vitro, impacting cell proliferation, apoptosis, migration, and invasion.
  • Mechanistic studies revealed that oxymatrine suppresses the expression of beta-catenin, mediating its antineoplastic effects.
  • In vivo experiments confirmed oxymatrine's remarkable inhibition of tumor growth in a nude mice model.

Conclusions:

  • Oxymatrine is identified as a potent antitumor agent against renal cell carcinoma.
  • The findings suggest oxymatrine holds promising therapeutic potential for treating renal cell carcinoma.
Keywords:
apoptosischemotherapy sensitivityinvasionmigrationoxymatrineproliferationrenal cell carcinomaβ-catenin

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