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Posterior Cortical Atrophy: Characteristics From a Clinical Data Registry.

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|June 26, 2020
PubMed
Summary
This summary is machine-generated.

Posterior cortical atrophy (PCA) often presents with reading difficulties in older women. Neuro-ophthalmologists play a key role in diagnosing PCA, identifying visual field defects common in these patients.

Keywords:
Alzheimer's diseaseBenson's syndromehigher-order visual dysfunctionneuro-ophthalmologypatient registryposterior cortical atrophy

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Area of Science:

  • Neuroscience
  • Ophthalmology

Background:

  • Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by higher-order visual dysfunction.
  • PCA is typically linked to Alzheimer's disease pathology but often presents to non-cognitive specialists.
  • Limited data exists on PCA presentation to specialists outside of cognitive neurology.

Purpose of the Study:

  • To investigate the clinical presentation of PCA in patients seen by neuro-ophthalmologists.
  • To compare PCA presentation in neuro-ophthalmology practices with published data from cognitive specialists.

Main Methods:

  • A retrospective chart review data-entry survey was distributed to members of the North American Neuro-Ophthalmology Society Listserv (NANOSnet).
  • Data from 38 PCA patients were collected via an online survey using REDCap.
  • Patient data were compared to published cohorts and survey data from cognitive specialists.

Main Results:

  • Data from 12 neuro-ophthalmologists on 38 patients revealed a mean age of 67.8 years, with 74% being female.
  • Reading difficulty was reported by 91% of patients; visual field testing frequently showed homonymous defects.
  • Common findings included poor performance in color vision and stereopsis.

Conclusions:

  • Patients with PCA presenting to neuro-ophthalmologists tend to be older, female, and report reading difficulties more often than those seen by cognitive specialists.
  • Neuro-ophthalmologists are crucial in diagnosing PCA, especially in older adults with unexplained visual symptoms.
  • Future PCA research should incorporate multidisciplinary specialists to improve understanding and treatment development.