Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Potential of Rehabilitation to Amplify Experience-Induced Myelin Plasticity and Remyelination in Multiple Sclerosis: A Narrative Review.

Current neurology and neuroscience reports·2026
Same author

Machine Learning and AI Applied to fNIRS Data Reveals Novel Brain Activity Biomarkers in Stable Subclinical Multiple Sclerosis.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same author

FLOW Trial - The effect of fluoxetine combined with exercise on motor recovery after stroke: an RCT.

Archives of physical medicine and rehabilitation·2026
Same author

Translingual neural stimulation to improve gait and balance in multiple sclerosis: A randomized controlled trial.

Archives of physical medicine and rehabilitation·2026
Same author

The experience of assistive technology use amongst older adults with multiple sclerosis depends on their device and environment.

Disability and rehabilitation. Assistive technology·2026
Same author

Body-weight supported treadmill or total body recumbent stepper for mobility-adapted cardiopulmonary exercise testing in multiple sclerosis patients with varying disability.

Frontiers in rehabilitation sciences·2026

Related Experiment Video

Updated: Dec 17, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.2K

Walking Training Enhances Corticospinal Excitability in Progressive Multiple Sclerosis-A Pilot Study.

Arthur R Chaves1, Augustine J Devasahayam1, Morten Riemenschneider2

  • 1Recovery and Performance Laboratory, Faculty of Medicine, L. A. Miller Centre, Memorial University of Newfoundland, St. John's, NL, Canada.

Frontiers in Neurology
|June 26, 2020
PubMed
Summary

Task-specific walking training improved neuroplasticity and reduced fatigue in people with progressive multiple sclerosis (MS). This intervention enhanced corticospinal excitability, offering potential benefits even for those with significant disability.

Keywords:
corticospinal excitabilityexercisefatigueneuroplasticityprogressive multiple sclerosisrehabilitationtranscranial magnetic stimulation

More Related Videos

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.7K
Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

9.3K

Related Experiment Videos

Last Updated: Dec 17, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

17.2K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.7K
Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

9.3K

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Exercise Physiology

Background:

  • Multiple sclerosis (MS) causes progressive disability through neurodegeneration and inflammation, impacting motor, cognitive, and sensory functions.
  • Diminished neuroplasticity contributes to accumulating disability in MS.
  • Aerobic exercise shows potential for enhancing neuroplasticity and corticospinal excitability.

Purpose of the Study:

  • To investigate the effects of 10-week task-specific walking training on corticospinal excitability in progressive MS patients with walking aids.
  • To assess changes in neuroplasticity and fatigue over time (pre-training, post-training, and 3-month follow-up).

Main Methods:

  • Eight participants with progressive MS (Expanded Disability Status Scale 6-6.5) underwent supervised treadmill walking training.
  • Training involved harness-supported walking for 10 weeks, three times weekly, 40 minutes per session at 40-65% heart rate reserve.
  • Corticospinal excitability was measured using single-pulse transcranial magnetic stimulation (TMS) at baseline, post-intervention, and follow-up.

Main Results:

  • Significant increases in corticospinal excitability, reduced TMS active motor thresholds, and enhanced motor-evoked potential amplitudes were observed post-training.
  • Decreased intracortical inhibition was noted in the dominant hemisphere.
  • Improvements in corticospinal excitability correlated with reduced fatigue severity and impact, though effects were not sustained at follow-up.

Conclusions:

  • Vigorous treadmill training may enhance neuroplastic potential in individuals with progressive MS, even those with substantial accumulated disability.
  • This training approach shows promise for mitigating MS symptoms, particularly fatigue.
  • Pilot findings suggest walking rehabilitation as a viable strategy for improving outcomes in advanced MS.