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MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing
Leon Tribolet1, Emily Kerr2, Christopher Cowled1
1Health and Biosecurity, Australian Animal Health Laboratory, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Geelong, VIC, Australia.
Frontiers in Microbiology
|June 26, 2020
Summary
MicroRNAs (miRNAs) show promise as biomarkers for infectious diseases, aiding diagnosis and personalized medicine. New detection platforms are emerging for rapid, point-of-care testing.
Area of Science:
- Molecular Biology
- Infectious Diseases
- Biomarker Discovery
Background:
- MicroRNAs (miRNAs) are small, non-coding RNA molecules with regulatory roles in various diseases.
- miRNAs are stable in biofluids and have established quantification methods, making them attractive biomarkers.
- Application of miRNA biomarkers in infectious diseases lags behind other disease areas.
Purpose of the Study:
- To outline the benefits of miRNA biomarkers for diagnosing, managing, and treating infectious diseases.
- To explore the potential of miRNA biomarkers in advancing personalized medicine for infectious diseases.
- To discuss emerging miRNA detection platforms for point-of-care applications in infectious disease diagnostics.
Main Methods:
- Review of existing literature on miRNA biomarkers in infectious diseases.
- Analysis of the advantages of using miRNAs as diagnostic and prognostic markers.
- Discussion of current and novel miRNA detection technologies.
Main Results:
- miRNA biomarkers offer significant potential for early diagnosis and monitoring of infectious diseases.
- The use of miRNA signatures can facilitate personalized treatment strategies in infectious disease management.
- Emerging technologies are enabling rapid, point-of-care detection of miRNA biomarkers.
Conclusions:
- miRNA biomarkers represent a promising frontier for improving infectious disease diagnostics and therapeutics.
- Validation of miRNA biomarkers is crucial for their clinical implementation in infectious disease settings.
- Advancements in detection platforms are key to realizing the full potential of miRNA biomarkers for infectious diseases.
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