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Related Experiment Video

Updated: Dec 17, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Diabetic Nephropathy: Perspective on Extracellular Vesicles.

Yanfang Lu^1,2,3,4, Dongwei Liu^1,2,3,4, Qi Feng^1,2,3,4

¹Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Immunology

|June 26, 2020

Summary

Extracellular vesicles (EVs) play a role in diabetic nephropathy (DN) development and progression. Urinary EV contents show promise as potential biomarkers for early DN diagnosis and therapeutic targets.

Keywords:

cell–cell cross-talk diabetic nephropathy diagnosis biomarker exosomes extracellular vesicles microvesicles

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Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma

Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma

Published on: August 3, 2022

Area of Science:

Nephrology
Cell Biology
Biochemistry

Background:

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease with limited therapeutic options.
Extracellular vesicles (EVs) are cell-secreted nanoparticles involved in intercellular communication.
EVs, including exosomes and microvesicles, are implicated in the pathophysiology of DN.

Purpose of the Study:

To review the generation, isolation, and biological functions of EVs.
To summarize the current understanding of EV mechanisms in DN development.
To discuss the diagnostic potential of urinary EVs for DN.

Main Methods:

Literature review of studies on EVs and DN.
Analysis of EV biogenesis and cargo.
Evaluation of diagnostic markers in urinary EVs.

Main Results:

EVs participate in the complex pathophysiological processes of DN.
Urinary EV contents (miRNAs, mRNAs, proteins) are potential biomarkers for DN.
EVs offer insights into DN mechanisms and therapeutic strategies.

Conclusions:

EVs are crucial in DN pathogenesis and progression.
Urinary EVs hold significant diagnostic value for DN.
Further research into EVs could lead to novel DN therapies.