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Influence of age on epidermal growth factor receptor level in the rat brain
M Hiramatsu1, M Kashimata, A Sato
1Department of Dental Pharmacology, Josai Dental University, Saitama, Japan.
Experientia
|January 15, 1988
Abstract:
The influence of age on 125I-epidermal growth factor (EGF) binding to rat brain plasma membranes was investigated. The specific binding of EGF to membranes decreased gradually with age in both male and female rats. There was no significant difference in the specific binding between males and females. Scatchard analysis of the binding data showed that the decrease in EGF binding with age was due to a decrease in the number of EGF receptors.