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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Dec 17, 2025

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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Current and Emerging Biomarkers Predicting Bone Metastasis Development.

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  • 1Medical Oncology, Bio-Medico University of Rome, Rome, Italy.

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|June 26, 2020
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Identifying early predictors for bone metastases (BMs) is crucial for high-risk cancer patients. This review highlights biomarkers that may help predict BMs, enabling timely interventions and improved quality of life.

Keywords:
CTCsDTCsbone metastasesbone turnover markersctDNAmiRNAs

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Area of Science:

  • Oncology
  • Biomarkers
  • Skeletal Metastases

Background:

  • Bone is a common site for distant metastases, particularly in breast and prostate cancers.
  • Bone metastases (BMs) lead to skeletal-related events, significantly impacting patient quality of life.
  • Current research primarily focuses on BM pathophysiology and treatment, with limited investigation into predictive risk factors.

Purpose of the Study:

  • To review existing evidence on biomarkers that can predict the early development of bone metastases.
  • To identify potential tools for early risk stratification of patients likely to develop BMs.

Main Methods:

  • Literature review summarizing current evidence on biomarkers for bone metastasis prediction.
  • Analysis of studies investigating molecular mechanisms and risk factors for BMs.

Main Results:

  • Several specific biomarkers show potential for early prediction of bone metastasis development.
  • The identification of high-risk patients could facilitate early intervention strategies.

Conclusions:

  • Biomarker-based prediction of bone metastases is an emerging area with significant clinical potential.
  • Early identification of at-risk individuals can guide preventative strategies and improve patient outcomes.