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The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

Parimal Samir1, R K Subbarao Malireddi1, Thirumala-Devi Kanneganti1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, United States.

Frontiers in Cellular and Infection Microbiology
|June 26, 2020
PubMed

Insights

Programmed cell death pathway PANoptosis is regulated by the PANoptosome complex, which orchestrates pyroptosis, apoptosis, and necroptosis. This complex is implicated in various human diseases, offering insights into disease mechanisms.

Area of Science:

  • Cellular Biology
  • Immunology
  • Molecular Biology

Background:

  • Programmed cell death is crucial for development and immunity.
  • PANoptosis is a newly identified proinflammatory cell death pathway.
  • The PANoptosome complex regulates PANoptosis.

Purpose of the Study:

  • To review PANoptosome components.
  • To perform phylogenetic analysis of PANoptosome components.
  • To propose mechanistic models for PANoptosome assembly.

Main Methods:

  • Literature review of PANoptosome components.
  • Phylogenetic analysis of molecular domains and interaction motifs.
  • Analysis of genetic data on PANoptosis coordination.

Main Results:

  • Identification of putative PANoptosome components.
  • Phylogenetic analysis supports complex assembly.
  • Genetic data suggest scaffolding and catalytic roles.

Conclusions:

  • PANoptosis is coordinated by the PANoptosome complex.
  • Evolutionary analysis provides insights into PANoptosis mechanisms.
  • Understanding PANoptosis is relevant to human diseases.
Keywords:
ASCPANoptosisPANoptosomeRIPK1RIPK3ZBP1caspase-1caspase-8

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