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Pre-discharge Cardiorespiratory Monitoring in Preterm Infants. the CORE Study

Francesco Cresi1, Enrico Cocchi1, Elena Maggiora1

  • 1Neonatal Intensive Care Unit, City of Health and Science-University of Turin, Turin, Italy.

Insights

The CORE protocol significantly reduced hospital readmissions in preterm infants by monitoring cardiorespiratory stability before discharge. This new approach ensures safer discharges without extending hospital stays.

Area of Science:

  • Neonatology
  • Pediatric Cardiology
  • Clinical Research

Background:

  • Cardiorespiratory (CR) stability is critical for safe infant discharge from neonatal intensive care units (NICUs).
  • Hospital readmission (RHR) is a significant concern for preterm infants post-discharge.
  • Optimizing discharge protocols is essential to improve infant outcomes and reduce healthcare burdens.

Purpose of the Study:

  • To evaluate the impact of a novel pre-discharge protocol, CORE, on the risk of hospital readmission in preterm infants.
  • To assess whether the CORE protocol influences the length of hospital stay for preterm infants.

Main Methods:

  • A randomized controlled trial involving preterm infants admitted to the NICU between 2015 and 2018.
  • Infants were assigned to either the CORE protocol (exposed) or a standard discharge protocol (not-exposed).
  • The CORE protocol involved 24-hour clinical observation and, for high-risk infants, 24-hour instrumental CR monitoring.

Main Results:

  • Three hundred twenty-three preterm infants were enrolled in the study.
  • Infants managed with the CORE protocol exhibited a significantly lower risk of hospital readmission (log-rank p < 0.05).
  • The reduction in RHR was particularly notable at 3 months post-discharge (9.09% vs. 21.6%; p = 0.004).

Conclusions:

  • The CORE protocol demonstrates potential in optimizing discharge timing for preterm infants.
  • Implementation of the CORE protocol may lead to a reduction in hospital readmissions.
  • The CORE protocol did not result in a significant increase in the length of hospital stay.

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