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Pre-discharge Cardiorespiratory Monitoring in Preterm Infants. the CORE Study
Francesco Cresi1, Enrico Cocchi1, Elena Maggiora1
1Neonatal Intensive Care Unit, City of Health and Science-University of Turin, Turin, Italy.
Insights
The CORE protocol significantly reduced hospital readmissions in preterm infants by monitoring cardiorespiratory stability before discharge. This new approach ensures safer discharges without extending hospital stays.
Area of Science:
- Neonatology
- Pediatric Cardiology
- Clinical Research
Background:
- Cardiorespiratory (CR) stability is critical for safe infant discharge from neonatal intensive care units (NICUs).
- Hospital readmission (RHR) is a significant concern for preterm infants post-discharge.
- Optimizing discharge protocols is essential to improve infant outcomes and reduce healthcare burdens.
Purpose of the Study:
- To evaluate the impact of a novel pre-discharge protocol, CORE, on the risk of hospital readmission in preterm infants.
- To assess whether the CORE protocol influences the length of hospital stay for preterm infants.
Main Methods:
- A randomized controlled trial involving preterm infants admitted to the NICU between 2015 and 2018.
- Infants were assigned to either the CORE protocol (exposed) or a standard discharge protocol (not-exposed).
- The CORE protocol involved 24-hour clinical observation and, for high-risk infants, 24-hour instrumental CR monitoring.
Main Results:
- Three hundred twenty-three preterm infants were enrolled in the study.
- Infants managed with the CORE protocol exhibited a significantly lower risk of hospital readmission (log-rank p < 0.05).
- The reduction in RHR was particularly notable at 3 months post-discharge (9.09% vs. 21.6%; p = 0.004).
Conclusions:
- The CORE protocol demonstrates potential in optimizing discharge timing for preterm infants.
- Implementation of the CORE protocol may lead to a reduction in hospital readmissions.
- The CORE protocol did not result in a significant increase in the length of hospital stay.
Abstract:
Objective: Ensuring cardiorespiratory (CR) stability is essential for a safe discharge. The aim of this study was to assess the impact of a new pre-discharge protocol named CORE on the risk of hospital readmission (RHR). Methods: Preterm infants admitted in our NICU between 2015 and 2018 were randomly assigned to CORE (exposed) or to standard (not-exposed) discharge protocol. CORE included 24 h-clinical observation, followed by 24 h-instrumental CR monitoring only for high-risk infants. RHR 12 months after discharge and length of stay represent the primary and secondary outcomes, respectively. Results: Three hundred and twenty three preterm infants were enrolled. Exposed infants had a lower RHR (log-rank p < 0.05). The difference was especially marked 3 months after discharge (9.09 vs. 21.6%; p = 0.004). The hospital length of stay in exposed and not-exposed infants was 39(26-58) and 43(26-68) days, respectively (p = 0.16). Conclusions: The CORE protocol could help neonatologists to define the best timing for discharge reducing RHR without lengthening hospital stay.
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