Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity

Area of Science:

• Cardiology
• Toxicology
• Molecular Biology

Background:

• Homeostatic regulation of cardiomyocytes is vital for cardiac function.
• Drug-induced cardiotoxicity leads to serious cardiac diseases like arrhythmia and myocardial infarction.
• Certain clinical drugs, including anti-cancer and anti-diabetic agents, can cause cardiotoxicity.

Purpose of the Study:

• To review cardiomyocyte death forms and mechanisms in drug-induced cardiotoxicity.
• To identify key proteins involved in cardiomyocyte death signaling pathways.
• To provide a theoretical basis for preventing and treating drug-induced cardiotoxicity.

Main Methods:

• Literature review of studies on drug-induced cardiotoxicity.
• Analysis of cardiomyocyte death pathways: apoptosis, autophagy, necrosis, necroptosis, pyroptosis, and ferroptosis.
• Evaluation of key proteins in cardiomyocyte death signaling.

Main Results:

• Drug-induced cardiotoxicity manifests through diverse cardiomyocyte death mechanisms.
• Specific proteins are critical in mediating these death pathways.
• Understanding these mechanisms and proteins is essential for clinical management.

Conclusions:

• Drug-induced cardiotoxicity is a significant clinical challenge.
• Targeting cardiomyocyte death pathways and proteins offers potential therapeutic strategies.
• This review provides a foundation for developing interventions against drug-induced heart damage.