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Autophagy regulation by microRNAs in chemotherapy resistance (Review)

Tianqiao Huang1, Zhen Xu1, Lin Cao2

  • 1Department of Otolaryngology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Oncology Reports
|June 26, 2020
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of autophagy, a process that impacts chemotherapy resistance in tumors. Targeting miRNAs involved in autophagy may overcome drug resistance and improve cancer treatment efficacy.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Chemotherapy is a cornerstone of cancer treatment, but drug resistance significantly limits its effectiveness.
  • Autophagy, a cellular degradation process, plays a crucial role in the development of chemoresistance.
  • MicroRNAs (miRNAs) are emerging as critical regulators of autophagy and chemoresistance.

Purpose of the Study:

  • To explore the role of microRNAs (miRNAs) in regulating autophagy-mediated chemoresistance.
  • To investigate the potential of targeting miRNA-autophagy pathways for overcoming drug resistance in cancer therapy.

Main Methods:

  • Literature review of recent advancements in chemotherapy, autophagy, and miRNA research.
  • Analysis of molecular mechanisms linking miRNAs, autophagy, and drug resistance.
  • Identification of key molecules and pathways involved in miRNA-regulated autophagy.

Main Results:

  • A significant number of molecules targeted by miRNAs are involved in the autophagic pathway.
  • miRNAs regulating autophagy influence the therapeutic efficacy of chemotherapy drugs.
  • miRNA-mediated autophagy modulation presents a promising strategy to overcome chemoresistance.

Conclusions:

  • MicroRNAs are critical regulators of autophagy and play a significant role in chemoresistance.
  • Targeting specific miRNAs involved in autophagy holds potential for enhancing chemotherapy effectiveness.
  • Further research into miRNA-autophagy interactions is warranted for clinical applications in overcoming drug resistance.
Keywords:
cancerautophagymiRNAchemotherapy resistance

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